Proteins are the vital molecular workhorses present in all living organisms. Proteomics applies technology to identify and quantify all proteins present in a cell, tissue or an organism, with the aim to understand how these proteins function and regulate life processes. This requires a detailed analyses of protein interactions, structures and modifications. As such, it is necessary to integrate proteomics technologies into world-class life sciences research programmes. The EU-funded EPIC-XS project brings together world-leading European proteomics facilities with the shared goal of supporting excellent life sciences research in Europe. Specifically, it will provide access to cutting-edge proteomics facilities and implement novel proteomics and bioinformatics approaches to support and shape life science research from bench to bedside.